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The upregulated include the efflux pumps (PDR5, ERC1, SNQ2, FEX2), membrane transporters (PMA1, PNS1, YLR413w, PRM10, WSC2, FLC2), transcription factors (HCM1, SKN7, SMP1, TBF1), enzymes (KDX1, DBP8, HMT1, AAA1, IME2, YHR033W)

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This process should include a comprehensive review of the manufacturers quality assurance practices, examination of certificates of analysis (COAs), verification of sterility and endotoxin testing, and confirmation of peptide identity, purity, and potency through validated analytical methods